For health professionals
Hemoglobal® began its mission in Sri Lanka guided by the academic focus of its founders, Drs. Nancy Olivieri and David Weatherall in the inherited disorders of hemoglobin. These disorders, including the thalassaemia syndromes and sickle cell disease, are the most common monogenic diseases worldwide. It has been estimated that approximately 7% of the world’s population are carriers for one of these disorders, and that up to half a million babies with the most severe forms are born annually. For the World Health Organization’s report on Hereditary Disease Community Control Programmes, please click here.
Improvements in nutrition and public health in emerging countries have resulted in an epidemiological transition characterized by a fall in mortality of children under the age of five years. Hence, children with serious diseases who would formerly have died in infancy, survive and require diagnosis and management, a trend that is now occurring throughout the Middle East, the Indian subcontinent, and in many parts of Asia. In 2006, the World Health Organization acknowledged thalassemia as a major global health problem.
Critically to the emerging focus of Hemoglobal® is that this improved survival has relevance to all forms of childhood illness. This is why Hemoglobal® will be expanding its goals to conducting research in children with other forms of severe disorders affecting the blood, including childhood leukemia and haemophilia.
PUBLICATIONS
Methemoglobinemia and absorbate deficiency in hemoglobin E beta thalassemia: metabolic and clinical implications
Allen A, Fisher C, Premawardhena A, Bandara D, Perere A, Allen S, St. Pierre T, Oliveiri N, Wearherall D.Methemoglobinemia and absorbate deficiency in hemoglobin E β thalassemia: metabolic and clinical implications.Blood 2012; 120(15):2939-44.Emerging insights in the management of hemoglobin E beta thalassemia
Olivieri NF, Thayalasuthan V, O’Donnell A, Premawardhena A, Rigobon C, Muraca G, Fisher C, Weatherall DJ. Emerging insights in the management of hemoglobin E beta thalassemia. Ann NY Acad. Sci 2010 1202: 155-157.Adaptation to anemia in hemoglobin E-beta thalassemia
Allen A, Fisher C, Premawardhena A, Peto T, Allen S, Arambepola M, Thayalsutha V, Olivieri N, Weatherall D. Adaptation to anemia in hemoglobin E-ß thalassemia. Blood. 2010 Dec 9;116(24):5368-70. doi: 10.1182/blood-2010-06-289488. Epub 2010 Sep 10. Erratum in: Blood. 2011 Dec 22; 118(26):6994-5. PubMed PMID: 20833979.Interaction of malaria with a common form of severe Thalassemia in an Asian population.
O’Donnell A, Premawardhena A, Arambepola M, Samaranayake R, Allen SJ, Peto TE, Fisher CA, Cook J, Corran PH, Olivieri NF, Weatherall DJ. Interaction of malaria with a common form of severe thalassemia in an Asian population. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18716-21. Epub 2009 Oct 19.PMID: 19841268.Studies in Haemoglobin E Beta-Thalassemia
Olivieri NF, Muraca GM, O’Donnell A, Premawardhena A, Weatherall DJ. Studies in Haemoglobin E Beta-Thalassemia. British Journal of Haematology 2008;141(3): 388-97.Age-related changes in adaption to severe anemia in childhood in developing countries
O’Donnell A, Premawardhena A, Arambepola M, Allen SJ, Peto TE, Fisher CA, Rees DC, Olivieri NF, Weatherall DJ. Age-related changes in adaption to severe anemia in childhood in developing countries. PNAS. 2007 104(22): 9440-4Hemoglobin E-beta thalassemia: Progress report from the International Study Group
Premawardhena A, DeSilva S, Arambepola M, Olivieri NF, Vichinsky EP, Merson L, Muraca G, Allen A, Fisher C, Peto T, Weatherall DJ. Hemoglobin E-ß thalassemia: Progress report from the International Study Group. Ann NY Acad. Sci 2005; 1054; 33-9.A novel molecular basis for {beta} thalassemia intermedia poses new questions about its pathophysiology
Premawardhena, A., Fisher, C.A., Olivieri, N.F., de Silva, S., Sloane-Stanley, J., Wood, W.G. & Weatherall, D.J. A novel molecular basis for {beta} thalassemia intermedia poses new questions about its pathophysiology. Blood 2005; 106(9): 3251-5Thalassemia in Sri Lanka: a progress report
Premawardhena A, De Silva S, Arambepola M, Olivieri N, Merson L, Muraco J, Allen A, Fisher C, Peto T, Vichinsky E, Weatheral D. Thalassemia in Sri Lanka: a progress report. Human Molecular Genetics 2004; R203-6, 2004.Genetic determinants of jaundice and gallstones in haemoglobin E beta thalassaemia.
Premawardhena A, Fisher CA, Fathiu F, de Silva S, Perera W, Peto TE, Olivieri NF, Weatherall DJ. Genetic determinants of jaundice and gallstones in haemoglobin E beta thalassaemia. Lancet 2001; 357: 1945-6.